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SICHEMSICHEM GMBH
MIRIAM RITTNER 博士 Miriam在哥廷根大学城长大。她在维尔茨堡和柏林学习化学。她在著名的Hahn-Meitner研究所撰写了毕业论文，并在柏林的Charité完成了博士论文。 哈特穆特·吉兰特博士 哈特穆特在不来梅附近长大，在不来梅大学学习化学，然后获得博士学位。随后，他在美国西雅图的Inologic公司进行了较长时间的研究。2001 年，他与他人共同创立了 Sirius Fine Chemcials SiChem GmbH，并担任董事总经理，负责研发工作。 CARSTEN SCHULTZ 博士 Carsten目前是俄勒冈健康与科学大学（OHSU）化学生理学和生物化学系的教授和系主任。他在不来梅学习化学，并在加州大学圣地亚哥分校与诺贝尔奖获得者 Roger Tsien 一起做博士后。毕业后，他去了多特蒙德的马克斯-普朗克分子生理学研究所，然后去了海德堡著名的欧洲分子生物学实验室（EMBL）。 除其他外，他开发了新型化学生物学工具，旨在非侵入性地监测和操纵完整细胞。主要兴趣仍然是肺部炎症和囊性纤维化（例如FRET传感器）。他进一步扩展到其他主题，即使用遗传密码扩展 （GCE） 和非经典氨基酸 （ncAA） 以最小的结构改变标记完整细胞中的蛋白质（超快点击化学）。 质量 我们已根据 DIN EN ISO 9001 实施了记录在案的质量管理体系，并致力于维护和不断改进该体系及其有效性。我们提供必要的手段和资源。 质量管理体系及其文档不断适应不断变化的条件。 在此过程中，我们考虑： 最先进的技术 监管应收账款 标准现状 关于质量问题的反馈 客户满意度 相关方的期望 我们的业绩概况 健康保护以及员工的资格和积极性 保护环境 我们行动的经济效率 质量管理流程的风险和机遇 我们有意识地选择质量管理体系作为指导和有效和高效运作的工具。在此过程中，我们非常重视我们的管理责任，并努力通过我们自己的榜样来培养所有员工对公司管理层的信任。 我们记录了公司的流程，并在必要时将其记录在流程描述中，同时考虑到质量管理体系的要求。我们以流程为导向的质量管理体系确保了执行和记录流程所需的手段、资源和信息的可用性。确定了这些过程的顺序和相互作用，以及实施、控制、监测、测量和分析的标准和方法。 所有流程均按照基本规范、监管和法律要求的要求进行管理。如果我们决定从外部提供可能影响产品符合我们要求的流程，我们将通过适当的措施（例如合同设计、审核和进货检查）在选择外部供应商的框架内确保始终控制此类外部提供的流程。 在分析相关相关方的背景和要求的基础上，我们制定了质量管理体系的质量方针和质量目标，并在公司内部公布。我们确保质量政策和目标在公司内部得到理解和应用，并确保相关相关方可以使用它们。我们每年都会进行一次管理评估。我们检查、评估和记录质量管理体系和质量政策的适用性和有效性，以及既定质量目标的实现情况。必要时，从评估中得出纠正和/或调整的措施。 我们在质量管理手册中记录了我们的质量管理体系。描述了适用于我们公司的所有程序和责任。该手册旨在向我们的员工、客户、合作伙伴、外部供应商以及主管当局和其他机构的代表证明，SiChem 维护着一个有效的质量管理体系，其中所有工作都是使用基于风险的思维来计划、控制和执行的。 管理层承诺促进质量管理体系的改进，并及时识别可能影响质量管理体系的变化，对其进行适当评估，并及时将相关信息传递给认证机构，并在必要时传递给其他相关方。 我们尊重客户和员工的隐私，并遵守有关数据保护的法律规定。业务、运营和客户相关数据均需保密。这也适用于合同工作和开发项目。在个人和公司相关数据的电子处理中，每个员工都有遵守法律和公司规定的合同义务。商业信息的保密性也是我们雇佣合同的一部分。 质量管理手册具有指导性质，对公司的所有员工（包括管理层）都具有约束力。每年验证指定的要求是否符合要求。本手册受法律保护。只有在征得 SiChem 同意的情况下，才能以任何其他形式复制、分发或提供给第三方。 DR. MIRIAM RITTNER Miriam grew up in the university town of Göttingen. She studied chemistry in Würzburg and Berlin. She wrote her diploma thesis at the renowned Hahn-Meitner-Institute and completed her doctoral thesis at the Charité in Berlin. DR. HARTMUT GILLANDT Hartmut grew up near Bremen and studied chemistry at the University of Bremen before earning his doctorate. He then spent a longer research period at Inologic Inc. in Seattle, USA. In 2001, he co-founded Sirius Fine Chemcials SiChem GmbH and, as managing director, is responsible for R&D. DR. CARSTEN SCHULTZ Carsten is currently a Professor and chairs the Department of Chemical Physiology and Biochemistry at Oregon Health & Science University (OHSU). He studied Chemistry in Bremen and worked than as postdoc with the Nobel laureate Roger Tsien at the University of California San Diego. After his habilitation he went to the Max-Planck-Institute for Molecular Physiology in Dortmund and then to the prestigious European Molecular Biology Laboratory in Heidelberg (EMBL). He developed among other things novel chemical biology tools designed to monitor and manipulate intact cells non-invasively. A main interest remained lung inflammation and cystic fibrosis (e.g. FRET sensors). He expanded further into additional topics, namely, the use of genetic code expansion (GCE) and non-canonical amino acids (ncAAs) for labeling proteins in intact cells with minimal structural alterations (ultrafast click chemistry). QUALITY We have implemented a documented quality management system in accordance with DIN EN ISO 9001 and are committed to maintaining and continuously improving this system and its effectiveness. The necessary means and resources are provided by us. The quality management system and its documentation are constantly adapted to changing conditions. IN DOING SO, WE TAKE INTO ACCOUNT: state of the art regulatory receivables status of standards feedback about quality problems customer satisfaction expectations of interested parties our performance profile health protection as well as qualification and motivation of our employees protection of the environment economic efficiency of our actions risks and opportunities of quality management processes We have consciously opted for a quality management system as a tool for steering and for the effective and efficient functioning of our organization. In doing so, we take our management responsibility very seriously and strive to develop the trust of all employees in the company management through our own role model. We have recorded our company processes and, where necessary, documented them in process descriptions, taking into account the requirements of the quality management system. Our process-oriented quality management system ensures the availability of the means, resources and information required to carry out and record the processes. The sequence and interactions of the processes as well as the criteria and methods for their implementation, control, monitoring, measurement and analysis were defined. All processes are managed in accordance with the requirements of the underlying normative, regulatory and legal requirements. If we decide to have processes made available externally that can have an influence on product conformity with our requirements, we ensure the control of such externally provided processes at all times within the framework of the selection of external providers through suitable measures such as e.g. contract design, auditing and incoming goods inspections. On the basis of an analysis of the context and requirements of relevant interested parties, we have defined a quality policy and quality objectives for the quality management system and made them known within the company. We ensure that quality policy and objectives are understood and applied within the company and that they are available to relevant interested parties. We carry out a management evaluation every year. We check, evaluate and document the suitability and effectiveness of the quality management system and the quality policy, as well as the fulfilment of the set quality goals. Where necessary, measures for correction and / or adjustment are derived from the evaluation. We have documented our quality management system in the quality management manual. All procedures and responsibilities that apply in our company are described. The handbook is intended to document to our employees, customers, cooperation partners, external suppliers and representatives of the responsible authorities and other institutions that SiChem maintains an effective quality management system in which all work is planned, controlled and carried out using risk-based thinking. The management undertakes to promote the improvement of the quality management system and to identify changes that could affect the quality management system in good time, to evaluate them appropriately and to pass on relevant information promptly to the certifier and, if necessary, other interested parties. We respect the privacy of our customers and employees and comply with the legal regulations on data protection. Business, operational and customer-related data are subject to secrecy. This also applies to contract work and development projects. In the electronic processing of personal and company-related data, every employee has the contractual obligation to comply with statutory and company regulations. The secrecy of business information is also part of our employment contracts. The quality management manual is of an instructional nature and is binding for all employees in the company, including the management. The specified requirements are verified annually for compliance. The manual enjoys legal protection. It may only be duplicated, distributed or made accessible to third parties in any other form with the consent of SiChem. 产品目录 (E)-cyclooct-4-en active ester / TCO/E- active ester (p-NPE) / equatorial (E)-cyclooct-4-en active ester / TCO4 / A- active ester (p-NPE) / axial (E)-cyclooct-4-enol / axial - TCO4 / A (E)-cyclooct-4-enol / equatorial - TCO / E (E)-cyclooctene doxorubicin conjugate / axial (E)-cyclooctene doxorubicin conjugate / equatorial 3-Azido-7-(diethylamino)-coumarin 12-Azidododecanoic acid Alkyne - PEG2 Alkyne - PEG2 - CM Alkyne - PEG2 - TCA Aminopentyl - Tetrazine - HCl-salt Aminopropyl - Tetrazine - HCl-salt Azido - PEG1 Azido - PEG2 - CM Azido - PEG2 - TCA BCN-3,5-diene-9-methanol BCN-endo-PEG2-Maleimide BCN-endo-PEG2-NH2 BCN-endo-PEG3-COOH BCN-endo-PEG3-Maleimide BCN-endo-PEG3-NH2 BCN-endo-PEG3-NHS BCN-endo-PEG4-COOH BCN-endo-PEG4-NHS BCN-endo-PEG7-Maleimide BCN-endo-PEG7-NH2 BCN-endo-PEG8-COOH BCN-endo-PEG8-NHS BCN-exo-PEG2-Maleimide BCN-exo-PEG2-NH2 BCN-exo-PEG3-COOH BCN-exo-PEG3-Maleimide BCN-exo-PEG3-NH2 BCN-exo-PEG3-NHS BCN-exo-PEG4-COOH BCN-exo-PEG4-NHS BCN-exo-PEG7-Maleimide BCN-exo-PEG7-NH2 BCN-exo-PEG8-COOH BCN-exo-PEG8-NHS bifunctional Cross-Linking-Amino-Acid / PrDiAzK Biotin-PEG2-N3 Biotin-PEG3-Alkyne Biotin-PEG3-Me-Tet Biotin-PEG3-N3 Biotin-PEG4-Alkyne Biotin-PEG4-Me-Tet Biotin-PEG7-N3 Biotin-PEG8-Alkyne Biotin-PEG8-Me-Tet Boc-N-Amido-PEG2-N3 Boc-N-Amido-PEG3-Alkyne Boc-N-Amido-PEG3-N3 Boc-N-Amido-PEG4-Alkyne Boc-N-Amido-PEG7-N3 Click Amino Acid (95%) / SCO - L - Lysine Click Amino Acid (99%) / SCO - L - Lysine - HCO2H-salt Click Amino Acid / cyclopropene – L - Lysine (CP) Click Amino Acid / endo BCN - L - Lysine Click Amino Acid / endo-BCN – Fmoc – L - Lysine (BCN) Click Amino Acid / exo BCN - L - Lysine Click Amino Acid / exo-BCN – Fmoc – L - Lysine (BCN) Click Amino Acid / Norbonene-CH2 – L - Lysine (NBO) Click Amino Acid / Norbornene-O – L - Lysine (NBO) Click Amino Acid / rac BCN - L - Lysine Click Amino Acid / trans-Cyclooct-2-en – L - Lysine (TCO*A) Click Amino Acid / trans-Cyclooct-4-en – L - Lysine (TCO4) / AXIAL isomer Click Amino Acid / trans-Cyclooct-4-en – L - Lysine (TCO4/EQ) / EQUATORIAL isomer Click-Amino-Acid / N3-Lys Click-Amino-Acid / PrK - HCl-salt Coumarin-C2-exoBCN Coumarin-C2-TCO*/axial Coumarin-PEG2-endoBCN Coumarin-PEG2-exoBCN Coumarin-PEG2-SCO Coumarin-PEG2-TCO*/axial Coumarin-PEG3-TCO*/axial Coumarin-PEG4-Tetrazine Coumarin-PEG7-TCO*/axial Coumarin-PEG8-Tetrazine Cross-Linking-Amino-Acid / DiAzK Cy3-PEG2-Azide Cy3-PEG2-endo-BCN Cy3-PEG2-exo-BCN Cy3-PEG2-SCO Cy3-PEG2-TCO* Cy3-PEG2-TCO4 Cy3-PEG3-Alkyne Cy3-PEG3-Azide Cy3-PEG3-endo-BCN Cy3-PEG3-exo-BCN Cy3-PEG3-SCO Cy3-PEG3-TCO* Cy3-PEG4-Alkyne Cy3-PEG7-Azide Cy3-PEG7-endo-BCN Cy3-PEG7-exo-BCN Cy3-PEG7-SCO Cy3-PEG7-TCO* Cy3-PEG7-TCO4 Cy3-PEG8-Alkyne Cy5-PEG2-endo-BCN Cy5-PEG2-exo-BCN Cy5-PEG2-SCO Cy5-PEG2-TCO* Cy5-PEG2-TCO4 Cy5-PEG3-endo-BCN Cy5-PEG3-exo-BCN Cy5-PEG3-SCO Cy5-PEG3-TCO* Cy5-PEG3-TCO4 Cy5-PEG7-endo-BCN Cy5-PEG7-exo-BCN Cy5-PEG7-SCO Cy5-PEG7-TCO* Cy5-PEG7-TCO4 DiAz-NHSE EdU EdUTP EdUTP-TEA endo BCN - active ester (p-NPE) endo BCN - OH endo-BCN-NHS carbonate Ethyl 2-methyl-3-(trimethylsilyl)cycloprop-2-ene-1-carboxylate exo BCN - active ester (p-NPE) exo BCN - OH exo-BCN-NHS carbonate Me-Tet-PEG2-COOH Me-Tet-PEG2-NHS Me-Tet-PEG3-Maleimide Me-Tet-PEG3-NH2 Me-Tet-PEG3-NHBoc Me-Tet-PEG4-COOH Me-Tet-PEG4-Maleimide Me-Tet-PEG4-NH2 Me-Tet-PEG4-NHBoc Me-Tet-PEG4-NHS Me-Tet-PEG5-COOH Me-Tet-PEG5-NHS Me-Tet-PEG8-Maleimide Me-Tet-PEG8-NH2 - HCl salt Me-Tet-PEG8-NHBoc Me-Tet-PEG9-COOH Me-Tet-PEG9-NHS Methyl-Tetrazine - Amine- HCO2H-salt N3-PEG3-t-butyl ester N3-PEG4-t-butyl ester N3-PEG5-t-butyl ester N3-PEG8-t-butyl ester N-Trifluoro-Acetylpropargylamine Pr-DiAz-COOH Pr-DiAz-NH2 Pr-DiAz-NHSC Pr-DiAz-NHSE Pr-DiAz-OH SCO - active ester (p-NPE) SCO - OH SCO-NHS carbonate SCO-PEG2-Maleimide SCO-PEG2-NH2 SCO-PEG3-COOH SCO-PEG3-Maleimide SCO-PEG3-NH2 SCO-PEG3-NHS SCO-PEG4-COOH SCO-PEG4-NHS SCO-PEG7-Maleimide SCO-PEG7-NH2 SCO-PEG8-COOH SCO-PEG8-NHS TAMRA-PEG2-N3 TAMRA-PEG3-Alkyne TAMRA-PEG3-Me-Tet TAMRA-PEG3-N3 TAMRA-PEG4-Alkyne TAMRA-PEG4-Me-Tet TAMRA-PEG7-N3 TAMRA-PEG8-Alkyne TAMRA-PEG8-Me-Tet TCO* - NHS carbonate / AXIAL isomer TCO* - NHS carbonate / EQUATORIAL isomer TCO*A - active ester (p-NPE) TCO*A - OH /AXIAL TCO*A - OH /EQUATORIAL TCO*E - active ester (p-NPC) / equatorial TCO*-PEG2-Maleimide TCO*-PEG2-NH2 TCO*-PEG3-COOH TCO*-PEG3-Maleimide TCO*-PEG3-NH2 TCO*-PEG3-NHS TCO*-PEG4-COOH TCO*-PEG4-NHS TCO*-PEG7-Maleimide TCO*-PEG7-NH2 TCO*-PEG8-COOH TCO*-PEG8-NHS TCO4 - NHS carbonate / AXIAL isomer TCO4 - NHS carbonate / EQUATORIAL isomer TCO4-PEG2-Maleimide TCO4-PEG2-NH2 TCO4-PEG3-COOH TCO4-PEG3-Maleimide TCO4-PEG3-NH2 TCO4-PEG3-NHS TCO4-PEG4-COOH TCO4-PEG4-NHS TCO4-PEG7-Maleimide TCO4-PEG7-NH2 TCO4-PEG8-COOH TCO4-PEG8-NHS Tetrazine - Amine - HCO2H-salt Tetrazine - Amine - TFA-salt Tetrazine active ester (Tetrazine-NHS) 上一篇CHEM-IMPEX下一篇CAS |
